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The requirement to use DEA order form 222 specifically pertains to the ordering of Schedule I and II controlled substances. Morphine HCl injection, categorized as a Schedule II drug because it has a high potential for abuse and significant risk of dependency, falls under this regulation. The DEA Form 222 is a necessary document for legal pharmaceutical transactions involving these high-risk medications, ensuring that stringent control measures are maintained throughout the distribution process.

In contrast, mild analgesics, cough syrups containing codeine (depending on their formulation and concentration), and over-the-counter medications do not require a DEA order form. Mild analgesics are typically classified as non-controlled substances. Cough syrup that contains codeine may often be classified differently based on the amount of codeine present, and if it falls into a lower classification, it won't require the same stringent documentation. Over-the-counter medications are entirely exempt from such regulations, allowing them to be ordered freely without the need for any special forms. Thus, the distinction of morphine HCl as a Schedule II drug necessitates the use of DEA Form 222 for its procurement.